Protein C deficiency and thrombosis.

Protein C deficiency and mesenteric venous thrombosis.

A 22-year-old woman with a history of gestational toxicosis and oral contraceptive use for 3 years reported progressive vague abdominal pain and vomiting over a 2-day period, without constipation, followed by rectal bleeding. On physical examination in the emergency department, the patient was afebrile, her blood pressure was 110/70 mm Hg and her pulse rate was 80 beats/min. There was diffuse a...

Portal and mesenteric thrombosis revealing constitutional protein C deficiency.

Right atrial thrombosis associated with sagittal sinus thrombosis caused by protein C-S deficiency.

Right atrial thrombi may develop within the right atrium or may have peripheral venous origins that, on their way to the final destination site lodge in, right atrium. Right atrial thrombosis is classified as two type: A (mobile, thin) and B (non mobile and attached to atrial wall) that they are probably of cardiac origin due to local pathology, indwelling catheter, atrial fibrillation, stasis,...

[Protein C deficiency].

Severe protein C deficiency (i.e. protein C activity <1 IU dL(-1)) is a rare autosomal recessive disorder that usually presents in the neonatal period with purpura fulminans (PF) and severe disseminated intravascular coagulation (DIC), often with concomitant venous thromboembolism (VTE). Recurrent thrombotic episodes (PF, DIC, or VTE) are common. Homozygotes and compound heterozygotes often pos...

Deficiency of superoxide dismutase impairs protein C activation and enhances susceptibility to experimental thrombosis.

OBJECTIVE Clinical evidence suggests an association between oxidative stress and vascular disease, and in vitro studies have demonstrated that reactive oxygen species can have prothrombotic effects on vascular and blood cells. It remains unclear, however, whether elevated levels of reactive oxygen species accelerate susceptibility to experimental thrombosis in vivo. APPROACH AND RESULTS Using...